Science. 1991 May 17;252(5008):958-61.

Site-specific recombination between homologous chromosomes in Drosophila.

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Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, University of Chicago, IL 60637.

Abstract

The ability to mark a cell and its descendants genetically so that the resulting cell clone can be distinguished from neighboring cells facilitates studies in animal biology and development. A method of generating clones by inducing homologous mitotic recombination in Drosophila with a site-specific yeast recombinase is described. This method allows for frequent mosaicism after mitotic exchange is induced at predefined sites in the genome.

PMID:: 2035025; [PubMed - indexed for MEDLINE]

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GM25874-09/GM/NIGMS NIH HHS/United States

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