(a) Anisomycin infusions following either footshock (US_FOOT) or eyelidshock (US_EYE) selectively disrupt fear memory reconsolidation for the conditioned stimulus associated with the reactivated unconditioned stimulus [Drug x CS_TYPE x Reactivation-US_TYPE interaction (F(_1,24)=18.15, p<.001). Follow-up of the triple interaction with simple interaction effects indicated that anisomycin, following exposure to the US_FOOT (n=8 and n=6 for ANISO and ACSF, respectively) impairs freezing responding to the US_FOOT–paired conditioned stimulus (CS_FOOT), but does not affect freezing to the US_EYE–paired conditioned stimulus (CS_EYE) [ANOVA: significant main effects of drug (F(_1,12)=14.39, p<.01) and CS_TYPE (F(_1,12)=6.24, p<.05); and a significant CS_TYPE x drug interaction (F(_1,12)=8.60, p<.05)]. (b) Anisomycin infusions following an exposure to an US_EYE (n=8 and n=6 for ANISO and ACSF, respectively) impair freezing responding to the US_EYE–paired conditioned stimulus (CS_EYE), but do not affect freezing to the US_FOOT–paired conditioned stimulus (CS_FOOT) [ANOVA: significant main effects of drug (F(_1,12)=16.91, p<.01) and CS_TYPE (F(_1,12)=11.70, p<.01); and a significant CS_TYPE x drug interaction (F(_1,12)=9.57, p<.01)]. Asterisks (*) indicate a significant difference between groups; error bars indicate standard error.

(a) Anisomycin (ANISO) infusions following an exposure to the footshock unconditioned stimulus alone disrupt the reconsolidation of auditory fear conditioning to both CSa and CSb [ANOVA: significant main effect of drug (F(_1,14)=21.70, p<.001), n=7 and n= 9 for ACSF and ANISO, respectively]. (b) Amnesic effects of anisomycin do not reverse within 4 weeks [ANOVA: significant main effect of drug F(_1,12)=36.06, p<.0001), n=7 and n= 7 for ACSF and ANISO, respectively]. (c) Short-term memory is not affected by anisomycin [n=6 ACSF; n=7 ANISO; No significant effects of drug (p=.7), conditioned stimulus (p=.5), or drug x conditioned stimulus (p=.5)]. Asterisks (*) indicate a significant difference between groups; error bars indicate standard error.