Comment to "The pharmacopeial evolution of Intralipid injectable emulsion in plastic containers: from a coarse to a fine emulsion"

Anders Ellborg; Denise Ferreira; Javad Mohammadnejad; Torbjörn Wärnheim

doi:10.1016/j.ijpharm.2010.03.045

Comment to "The pharmacopeial evolution of Intralipid injectable emulsion in plastic containers: from a coarse to a fine emulsion"

Int J Pharm. 2010 Jun 15;392(1-2):198-200. doi: 10.1016/j.ijpharm.2010.03.045. Epub 2010 Mar 27.

Authors

Anders Ellborg¹, Denise Ferreira, Javad Mohammadnejad, Torbjörn Wärnheim

Affiliation

¹ Technical Development, Fresenius Kabi AB, Uppsala, Sweden.

PMID: 20347944
DOI: 10.1016/j.ijpharm.2010.03.045

Abstract

The droplet size distribution of 50 batches of multi-chamber bags containing the parenteral nutrition emulsions Intralipid (Kabiven and Kabiven Peripheral) or Structolipid (StructoKabiven and StructoKabiven Peripheral), respectively, has been investigated. The results show that the non-compounded lipid emulsions analysed are in compliance with the United States Pharmacopeia (USP) chapter 729, Method II limit for the droplet size distribution, PFAT(5)<0.05%.

Publication types

Comment

MeSH terms

Calibration
Drug Packaging / methods*
Drug Packaging / standards
Drug Stability
Fat Emulsions, Intravenous / chemistry
Fat Emulsions, Intravenous / standards*
Particle Size
Pharmacopoeias as Topic
Plastics / chemistry*
Reference Standards
Technology, Pharmaceutical / methods*
Technology, Pharmaceutical / standards

Substances

Fat Emulsions, Intravenous
Plastics