Display Settings:

Format

Send to:

Choose Destination
Placenta. 2010 May;31(5):365-72. doi: 10.1016/j.placenta.2010.02.012. Epub 2010 Mar 25.

Nuclear matrix association: switching to the invasive cytotrophoblast.

Author information

  • 1Department of Obstetrics and Gynecology, Wayne State University, 253 C. S. Mott Center, 275 E. Hancock St., Detroit, MI 48201, USA.

Abstract

Abnormal trophoblast invasion is associated with the most common and most severe complications of human pregnancy. The biology of invasion, as well as the etiology of abnormal invasion remains poorly understood. The aim of this study was to characterize the transcriptome of the HTR-8/SVneo human cytotrophoblast cell line which displays well characterized invasive and non-invasive behavior, and to correlate the activity of the transcriptome with nuclear matrix attachment and cell phenotype. Comparison of the invasive to non-invasive HTR transcriptomes was unremarkable. In contrast, comparison of the MARs on chromosomes 14-18 revealed an increased number of MARs associated with the invasive phenotype. These attachment areas were more likely to be associated with silent rather than actively transcribed genes. This study supports the view that nuclear matrix attachment may play an important role in cytotrophoblast invasion by ensuring specific silencing that facilitates invasion.

(c) 2010 Elsevier Ltd. All rights reserved.

PMID:
20346505
[PubMed - indexed for MEDLINE]
PMCID:
PMC2860059
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1
Figure 2
Figure 3
Figure 4
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk