J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):69-75. Epub 2010 Mar 24.

The role of the glucocorticoid receptor in inflammation and immunity.

Source

Leibniz Institute for Age Research - Fritz-Lipmann-Institute, Jena, Germany.

Abstract

Glucocorticoids are potent immunosuppressive agents with complex actions on immune cells evoking the following effects: inducing apoptosis, changing differentiation fate, inhibition of cytokine release, inhibition of migration and other features. Distinct molecular mechanisms of the glucocorticoid receptor (GR) contribute to different anti-inflammatory effects. Recently inflammatory models have been investigated using conditional knockout and function selective mice shedding light on critical cell types and molecular mechanisms of endogenous and therapeutic GC actions. Here we review the multiple effects of GCs on major immune cells, dendritic cells, myeloid cells and B- and T-lymphocytes and give a summary of studies using conditional GR knockout mice.

PMID:: 20346397; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Supplemental Content

Related citations

Review Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice. [Mol Cell Endocrinol. 2007]
Review Glucocorticoid receptor action in beneficial and side effects of steroid therapy: lessons from conditional knockout mice.
Kleiman A, Tuckermann JP. Mol Cell Endocrinol. 2007 Sep 15; 275(1-2):98-108. Epub 2007 May 18.
Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. [J Immunol. 2008]
Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis.
Wüst S, van den Brandt J, Tischner D, Kleiman A, Tuckermann JP, Gold R, Lühder F, Reichardt HM. J Immunol. 2008 Jun 15; 180(12):8434-43.
Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis. [J Clin Invest. 1996]
Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis.
Costas M, Trapp T, Pereda MP, Sauer J, Rupprecht R, Nahmod VE, Reul JM, Holsboer F, Arzt E. J Clin Invest. 1996 Sep 15; 98(6):1409-16.
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. [Nat Med. 2003]
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation.
Brewer JA, Khor B, Vogt SK, Muglia LM, Fujiwara H, Haegele KE, Sleckman BP, Muglia LJ. Nat Med. 2003 Oct; 9(10):1318-22. Epub 2003 Aug 31.
Review Mechanisms and resistance in glucocorticoid control of inflammation. [J Steroid Biochem Mol Biol. 2010]
Review Mechanisms and resistance in glucocorticoid control of inflammation.
Barnes PJ. J Steroid Biochem Mol Biol. 2010 May 31; 120(2-3):76-85. Epub 2010 Feb 25.

See reviews... See all...

Cited by 7 PubMed Central articles

Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. [PLoS One. 2012]
Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults.
Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. PLoS One. 2012; 7(1):e30148. Epub 2012 Jan 25.
Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization. [Dermatoendocrinol. 2011]
Dynamic nature of transcriptional regulation of nuclear receptor target genes in the context of chromatin organization.
Väisänen S, Matilainen J, Carlberg C. Dermatoendocrinol. 2011 Jul; 3(3):125-9. Epub 2011 Jul 1.
Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. [Proc Natl Acad Sci U S A. 2011]
Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells.
Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19317-22. Epub 2011 Nov 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The role of the glucocorticoid receptor in inflammation and immunity.
The role of the glucocorticoid receptor in inflammation and immunity.
J Steroid Biochem Mol Biol. 2010 May 31 ;120(2-3):69-75. Epub 2010 Mar 24 .

PubMed
Macrophages and neutrophils are the targets for immune suppression by glucocorti...
Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy.
J Clin Invest. 2007 May ;117(5):1381-90. Epub 2007 Apr 19 .

PubMed
Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric o...
Effects of mushroom-derived beta-glucan-rich polysaccharide extracts on nitric oxide production by bone marrow-derived macrophages and nuclear factor-kappaB transactivation in Caco-2 reporter cells: can effects be explained by structure?
Mol Nutr Food Res. 2010 Feb ;54(2):268-76.

PubMed
Huntington's disease. Part 2: treatment and management issues in juvenile HD.
Huntington's disease. Part 2: treatment and management issues in juvenile HD.
Br J Nurs. 2008 Feb 28-Mar 12 ;17(4):260-3.

PubMed
Celecoxib compared with sustained-release paracetamol for osteoarthritis: a seri...
Celecoxib compared with sustained-release paracetamol for osteoarthritis: a series of n-of-1 trials.
Rheumatology (Oxford). 2007 Jan ;46(1):135-40. Epub 2006 Jun 15 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: