Warning: The NCBI web site requires JavaScript to function. more...

My NCBI Sign In

J Med Chem. 2010 Jul 22;53(14):5061-84.

A medicinal chemist's guide to molecular interactions.

Bissantz C, Kuhn B, Stahl M.

Source

Discovery Chemistry, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland.

Erratum in

J Med Chem. 2010 Aug 26;53(16):6241.

PMID:: 20345171; [PubMed - indexed for MEDLINE]
PMCID: PMC2905122

Free PMC Article

Images from this publication.See all images (20) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Evaluations and comments from leading biologists - Faculty of 1000 Biology

Medical

Medicines - MedlinePlus Health Information

Supplemental Content

Click here to read

Click here to read

Related citations

Intramolecular hydrogen bonding in medicinal chemistry. [J Med Chem. 2010]
Intramolecular hydrogen bonding in medicinal chemistry.
Kuhn B, Mohr P, Stahl M. J Med Chem. 2010 Mar 25; 53(6):2601-11.
Review Physics-based methods for studying protein-ligand interactions. [Curr Opin Drug Discov Devel. 2007]
Review Physics-based methods for studying protein-ligand interactions.
Huang N, Jacobson MP. Curr Opin Drug Discov Devel. 2007 May; 10(3):325-31.
Review The role and significance of unconventional hydrogen bonds in small molecule recognition by biological receptors of pharmaceutical relevance. [Curr Pharm Des. 2007]
Review The role and significance of unconventional hydrogen bonds in small molecule recognition by biological receptors of pharmaceutical relevance.
Tóth G, Bowers SG, Truong AP, Probst G. Curr Pharm Des. 2007; 13(34):3476-93.
Review Molecular modeling of hydration in drug design. [Curr Opin Drug Discov Devel. 2007]
Review Molecular modeling of hydration in drug design.
Mancera RL. Curr Opin Drug Discov Devel. 2007 May; 10(3):275-80.
Review Structural biology and drug discovery. [Curr Pharm Des. 2006]
Review Structural biology and drug discovery.
Scapin G. Curr Pharm Des. 2006; 12(17):2087-97.

See reviews... See all...

Cited by 6 PubMed Central articles

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes. [J Med Chem. 2012]
7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes.
Huber K, Brault L, Fedorov O, Gasser C, Filippakopoulos P, Bullock AN, Fabbro D, Trappe J, Schwaller J, Knapp S, et al. J Med Chem. 2012 Jan 12; 55(1):403-13. Epub 2012 Jan 3.
Rationalizing tight ligand binding through cooperative interaction networks. [J Chem Inf Model. 2011]
Rationalizing tight ligand binding through cooperative interaction networks.
Kuhn B, Fuchs JE, Reutlinger M, Stahl M, Taylor NR. J Chem Inf Model. 2011 Dec 27; 51(12):3180-98. Epub 2011 Dec 9.
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. [Proc Natl Acad Sci U S A. 2011]
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.
Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, et al. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6757-62. Epub 2011 Apr 18.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A medicinal chemist's guide to molecular interactions.
A medicinal chemist's guide to molecular interactions.
J Med Chem. 2010 Jul 22 ;53(14):5061-84.

PubMed
The role of parathyroid hormone-related protein in the regulation of osteoclasto...
The role of parathyroid hormone-related protein in the regulation of osteoclastogenesis by cementoblasts.
J Periodontol. 2004 Sep ;75(9):1247-54.

PubMed
Imprinting and the epigenetic asymmetry between parental genomes.
Imprinting and the epigenetic asymmetry between parental genomes.
Science. 2001 Aug 10 ;293(5532):1086-9.

PubMed
Effects of opioids on the immune system.
Effects of opioids on the immune system.
Neurochem Res. 1996 Nov ;21(11):1375-86.

PubMed
Creating protein affinity reagents by combining peptide ligands on synthetic DNA...
Creating protein affinity reagents by combining peptide ligands on synthetic DNA scaffolds.
J Am Chem Soc. 2009 Dec 2 ;131(47):17233-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Literature > PubMed

Write to the Help Desk