Highly efficient and versatile pd-catalyzed direct alkynylation of both azoles and azolines

Seok Hwan Kim; Sukbok Chang

doi:10.1021/ol100488v

Highly efficient and versatile pd-catalyzed direct alkynylation of both azoles and azolines

Org Lett. 2010 Apr 16;12(8):1868-71. doi: 10.1021/ol100488v.

Authors

Seok Hwan Kim¹, Sukbok Chang

Affiliation

¹ Department of Chemistry and Molecular-Level Interface Research Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.

PMID: 20337427
DOI: 10.1021/ol100488v

Abstract

A highly efficient and versatile Pd-catalyzed direct alkynylation reaction of heterocycles with 1-bromoalkynes was developed. The substrate scope of the reaction was very broad to include not only azoles but also azolines for the first time, thus offering an important advance in the direct functionalization of heterocycles.