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Indian J Pharmacol. 2009 Apr;41(2):75-9. doi: 10.4103/0253-7613.51345.

Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities.

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  • 1Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India.

Abstract

OBJECTIVES:

Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models.

MATERIALS AND METHODS:

Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy's hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50 mg/kg and 100 mg/kg.

RESULTS:

The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P < 0.001). The maximum analgesic effect was observed at 120 min at the dose of 100 mg/kg (i.p.) and was comparable to that of standard analgin (150 mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50 mg/kg and 100 mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5 mg/kg).

CONCLUSION:

Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.

KEYWORDS:

Analgesic activity; Bauhinia purpurea Linn; anti-inflammatory activity; eddy's hot plate

PMID:
20336222
[PubMed]
PMCID:
PMC2841237
Free PMC Article
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