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Exerc Sport Sci Rev. 2010 Apr;38(2):76-85. doi: 10.1097/JES.0b013e3181d495d2.

Intracellular Ca2+ signaling in skeletal muscle: decoding a complex message.

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  • 1Department of Kinesiology, School of Public Health, University of Maryland, College Park, MD 20742, USA.


Intracellular calcium (Ca2+) plays an important role in regulating muscle force production, metabolism, and muscle gene expression. It is hypothesized that the precise pattern of Ca2+ oscillations, determined by the Ca2+ channels activated and the contributing Ca2+ pools, controls the coupling between neural activation, force production, cellular energetics, and gene expression. The physiological and cellular coordination between these events will be discussed.

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