Format

Send to:

Choose Destination
See comment in PubMed Commons below
Am J Clin Nutr. 2010 May;91(5):1499S-1505S. doi: 10.3945/ajcn.2010.28701B. Epub 2010 Mar 24.

Childhood obesity and adult morbidities.

Author information

  • 1University of Cincinnati College of Medicine, Division of Adolescent Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. frank.biro@cchmc.org

Abstract

The prevalence and severity of obesity have increased in recent years, likely the result of complex interactions between genes, dietary intake, physical activity, and the environment. The expression of genes favoring the storage of excess calories as fat, which have been selected for over many millennia and are relatively static, has become maladaptive in a rapidly changing environment that minimizes opportunities for energy expenditure and maximizes opportunities for energy intake. The consequences of childhood and adolescent obesity include earlier puberty and menarche in girls, type 2 diabetes and increased incidence of the metabolic syndrome in youth and adults, and obesity in adulthood. These changes are associated with cardiovascular disease as well as with several cancers in adults, likely through insulin resistance and production of inflammatory cytokines. Although concerns have arisen regarding environmental exposures, there have been no formal expert recommendations. Currently, the most important factors underlying the obesity epidemic are the current opportunities for energy intake coupled with limited energy expenditure.

PMID:
20335542
[PubMed - indexed for MEDLINE]
PMCID:
PMC2854915
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk