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J Dent Res. 2010 May;89(5):457-61. doi: 10.1177/0022034510363232. Epub 2010 Mar 24.

IL-1 gene cluster is not linked to aggressive periodontitis.

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  • 1Department of Biology and Evolution, University of Ferrara, Corso Ercole I d'Este 32, I-44100 Ferrara, Italy.


The interleukin-1 (IL-1) gene family has been associated with susceptibility to periodontal diseases, including aggressive periodontitis (AgP); however, the results are still conflicting. The present study investigated the association between IL-1 genes and AgP using 70 markers spanning the 1.1-Mb region, where the IL-1 gene family maps, and exploring both the linkage disequilibrium (LD) and the haplotype structure in a case-control study including 95 patients and 121 control individuals. No association between AgP and IL1A, IL1B, and IL1RN genes was found in either single-point or haplotype analyses. Also, the LD map of the region 2q13-14 under the Mal├ęcot model for multiple markers showed no causal association between AgP and polymorphisms within the region (p = 0.207). In conclusion, our findings failed to support the existence of a causative variant for generalized AgP within the 2q13-14 region in an Italian Caucasian population.

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