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Curr Biol. 2010 Mar 23;20(6):R285-95. doi: 10.1016/j.cub.2010.01.034.

Mechanisms of chromosomal instability.

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  • 1Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.

Abstract

Most solid tumors are aneuploid, having a chromosome number that is not a multiple of the haploid number, and many frequently mis-segregate whole chromosomes in a phenomenon called chromosomal instability (CIN). CIN positively correlates with poor patient prognosis, indicating that reduced mitotic fidelity contributes to cancer progression by increasing genetic diversity among tumor cells. Here, we review the mechanisms underlying CIN, which include defects in chromosome cohesion, mitotic checkpoint function, centrosome copy number, kinetochore-microtubule attachment dynamics, and cell-cycle regulation. Understanding these mechanisms provides insight into the cellular consequences of CIN and reveals the possibility of exploiting CIN in cancer therapy.

2010 Elsevier Ltd. All rights reserved.

PMID:
20334839
[PubMed - indexed for MEDLINE]
PMCID:
PMC3781365
Free PMC Article

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