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J Ethnopharmacol. 2010 May 27;129(2):214-9. doi: 10.1016/j.jep.2010.03.014. Epub 2010 Mar 21.

In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds.

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  • 1Faculdade de Veterinária, Universidade Estadual do Ceará (UECE), Campus do Itaperi, Fortaleza, Ceará, Brazil.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Caryocar coriaceum Wittm. (Caryocaraceae), popularly known as pequi, is important source of food and used in the folk medicine as wound healing, anti-inflammatory and for the treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer.

AIM OF THE STUDY:

To evaluate the effects of fixed oil of Caryocar coriaceum (FOCC) on the topical inflammation and cutaneous wound healing.

MATERIALS AND METHODS:

FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% on model of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excision model in mice. Skin lesions were evaluated by planimetry and histological analysis.

RESULTS:

FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%) inhibited the ear edema in 38.01% and 39.20% at time 15 min and 1h, respectively, after induction of inflammation, when compared to the positive control. The topical administration of FOCC ointment 12% showed a significantly reduction of unhealed wound area, with increased percentage of wound contraction (96.54%) on day 7 when compared to the other groups. The results of histological evaluation supported the outcome of excision wound model.

CONCLUSION:

Caryocar coriaceum inhibits the topical inflammation and accelerate cutaneous wound repair.

Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

PMID:
20332017
[PubMed - indexed for MEDLINE]
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