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Traffic. 2010 Jun;11(6):721-31. doi: 10.1111/j.1600-0854.2010.01061.x. Epub 2010 Mar 17.

Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.

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  • 1Nencki Institute of Experimental Biology, Pasteura 3 Street, 02-093 Warsaw, Poland.


Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.

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