Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Immunology. 2010 May;130(1):16-22. doi: 10.1111/j.1365-2567.2010.03265.x. Epub 2010 Mar 17.

Regulation of CD4 T-cell receptor diversity by vaccine adjuvants.

Author information

  • 1BloodCenter of Wisconsin, Blood Research Institute, Milwaukee, WI 53201, USA.

Abstract

New vaccines based on soluble recombinant antigens (Ags) require adjuvants to elicit long-lasting protective humoral and cellular immunity. Despite the importance of CD4 T helper cells for the generation of long-lived memory B and CD8 T cells, the impact of adjuvants on CD4 T-cell responses is still poorly understood. Adjuvants are known to promote dendritic cell (DC) maturation and migration to secondary lymphoid organs where they present foreign peptides bound to class II major histocompatibility complex molecules (pMHCII) to naïve CD4 T cells. Random and imprecise rearrangements of genetic elements during thymic development ensure that a vast amount of T-cell receptors (TCRs) are present in the naïve CD4 T-cell repertoire. Ag-specific CD4 T cells are selected from this vast pre-immune repertoire based on the affinity of their TCR for pMHCII. Here, we review the evidence demonstrating a link between the adjuvant and the specificity and clonotypic diversity of the CD4 T-cell response, and consider the potential mechanisms at play.

PMID:
20331477
[PubMed - indexed for MEDLINE]
PMCID:
PMC2855789
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing Icon for PubMed Central
    Loading ...
    Write to the Help Desk