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Eur J Orthod. 1991 Feb;13(1):75-80.

Growth of the cartilages of the mid-line cranial base of the Wistar rat: an autoradiographic study using 35S-sulphate.

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  • 1Department of Paediatric Dentistry, U.M.D.S., London.


Matrix synthesis in the mid-line cranial base of the rat was studied using a single injection of 35S-sulphate in animals aged 4-80 days. High uptake of 35S-sulphate in the morphologically distinct zone of early hypertrophy led to it being renamed the Matrixogenic Zone. Relocation of 35S-sulphate label into the primary spongiosa was used to estimate the growth rate of each site of endochondral ossification. This showed a marked caudorostral and temporal gradient. In addition, there was a caudorostral and temporal gradient in hypertrophic cell size, but only a temporal gradient in the rate of cell loss.

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