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Trends Genet. 1991 Mar;7(3):79-85.

Pre-mRNA splicing in yeast.

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  • 1Division of Biology, California Institute of Technology, Pasadena 91125.


Splicing of introns from nuclear precursor messenger RNAs (pre-mRNAs) occurs in all eukaryotes. Two aspects of the splicing mechanism need to be understood: how intron sequences are recognized and aligned and how splicing is catalysed. Recent genetic and biochemical studies in the simple eukaryote Saccharomyces cerevisiae are revealing some of the features of the splicing mechanism.

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