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Science. 1991 May 24;252(5009):1162-4.

Predicting coiled coils from protein sequences.

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  • 1Department of Molecular Biology, Princeton University, NJ 08544.

Abstract

The probability that a residue in a protein is part of a coiled-coil structure was assessed by comparison of its flanking sequences with sequences of known coiled-coil proteins. This method was used to delineate coiled-coil domains in otherwise globular proteins, such as the leucine zipper domains in transcriptional regulators, and to predict regions of discontinuity within coiled-coil structures, such as the hinge region in myosin. More than 200 proteins that probably have coiled-coil domains were identified in GenBank, including alpha- and beta-tubulins, flagellins, G protein beta subunits, some bacterial transfer RNA synthetases, and members of the heat shock protein (Hsp70) family.

PMID:
2031185
[PubMed - indexed for MEDLINE]
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