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Nat Rev Mol Cell Biol. 2010 Apr;11(4):276-87. doi: 10.1038/nrm2866.

Organizing the cell cortex: the role of ERM proteins.

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  • 1Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois 60637, USA.

Erratum in

  • Nat Rev Mol Cell Biol. 2010 Sep;11(9):674.


Specialized membrane domains are an important feature of almost all cells. In particular, they are essential to tissues that have a highly organized cell cortex, such as the intestinal brush border epithelium. The ERM proteins (ezrin, radixin and moesin) have a crucial role in organizing membrane domains through their ability to interact with transmembrane proteins and the cytoskeleton. In doing so, they can provide structural links to strengthen the cell cortex and regulate the activities of signal transduction pathways. Recent studies examining the structure and in vivo functions of ERMs have greatly advanced our understanding of the importance of membrane-cytoskeleton interactions.

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