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Oral Oncol. 2010 Jun;46(6):423-5. doi: 10.1016/j.oraloncology.2010.02.016. Epub 2010 Mar 21.

Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management.

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  • 1Department of Oral and Maxillofacial Surgery/Pathology, VU University Medical Center /Academic Centre for Dentistry Amsterdam, PO Box 7057, 1007 MB Amsterdam, The Netherlands. i.vanderwaal@vumc.nl

Abstract

In spite of tremendous progress in the field of molecular biology there is yet no single marker that reliably predicts malignant transformation of a potentially malignant disorder of the oral mucosa. Therefore, it is recommended to excise or laser any oral of oropharyngeal leukoplakia/erythroplakia, if feasible, irrespective of the presence or absence of dysplasia. However, it is actually unknown whether such removal truly prevents the possible development of a squamous cell carcinoma. Therefore, lifelong follow-up is recommended at intervals of no more than 6 months. At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable.

Copyright 2010 Elsevier Ltd. All rights reserved.

PMID:
20308005
[PubMed - indexed for MEDLINE]
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