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    Nature. 1991 May 9;351(6322):117-21.

    Male development of chromosomally female mice transgenic for Sry.

    Source

    Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.

    Abstract

    The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

    PMID:
    2030730
    [PubMed - indexed for MEDLINE]

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