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Nat Methods. 2010 Apr;7(4):299-301. doi: 10.1038/nmeth.1443. Epub 2010 Mar 21.

Direct determination of molecular haplotypes by chromosome microdissection.

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  • 1Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia, USA.

Abstract

Direct observation of haplotypes is still technically challenging. Here we report a method for the determination of haplotypes through chromosome microdissection. We determined human long-range chromosomal haplotypes with more than 98.85% accuracy at 24,245 genome-wide heterozygous single-nucleotide polymorphism (SNP) loci.

PMID:
20305652
[PubMed - indexed for MEDLINE]
PMCID:
PMC2871314
Free PMC Article

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