Crimean-Congo haemorrhagic fever is an emerging zoonosis with a wide geographic distribution and protean clinical manifestations. The main pathogenesis of this infection has not been elucidated. Erythema nodosum is an immunologically-mediated dermatologic disease and the most common form of panniculitis that has been associated with many infections and inflammatory disorders. We describe a case of Crimean-Congo haemorrhagic fever with severe bleeding diathesis and hepatic failure that was successfully treated with oral ribavirin. The patient presented with erythema nodosum in the course of disease. Crimean-Congo haemorrhagic fever and erythema nodosum have not been reported to occur together. We present the first reported case of erythema nodosum associated with this emerging viral infection. Furthermore, it may influence our opinion about pathogenesis and immunologic mechanisms of this disease.