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Clin Gastroenterol Hepatol. 2010 Jul;8(7):610-5. doi: 10.1016/j.cgh.2010.03.007. Epub 2010 Mar 19.

Low rates of cancer or high-grade dysplasia in colorectal polyps collected from computed tomography colonography screening.

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  • 1Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792-3252, USA. ppickhardt2@uwhealth.org



In patients with polyps detected at computed tomography colonography (CTC) screening, management decisions are influenced by the likelihood of important polyp histology. We assess the rates of cancer and high-grade dysplasia among patients found to have small (6-9 mm) and large (>or=10 mm) colorectal polyps at CTC.


We reviewed results from 5124 consecutive adults (mean age, 56.9 y; 2792 women) who received CTC screening at 1 institution over a 52-month period. All nondiminutive lesions confirmed at subsequent colonoscopy were grouped by size and histology features. Rates of cancer and high-grade dysplasia were calculated for various sizes. Adenomas were classified as advanced if they were 10 mm or greater and/or contained high-grade dysplasia or a prominent villous component.


A total of 755 polyps 6 mm or greater were identified during colonoscopy examinations in 479 patients. The rate of malignancy, according to polyp size, was 0% (0 of 464) for polyps 6 to 9 mm, 0.9% (2 of 216) for polyps 10 to 19 mm, 6.1% (2 of 33) for polyps 20 to 29 mm, and 38.1% (16 of 42) for polyps 30 mm or greater. High-grade dysplasia was observed in 0.4% (2 of 464) of 6- to 9-mm polyps and 7.9% (23 of 291) of lesions 10 mm or greater. A prominent villous component was seen in 3.4% (16 of 464) of 6- to 9-mm polyps. The overall rate of advanced histology in small polyps was 3.9% (18 of 464).


Small (6-9 mm) polyps rarely contained high-grade dysplasia (0.4%); none was malignant. The malignancy rate for large (1-2 cm) colorectal polyps was less than 1%. These findings indicate the potential for less aggressive management of lesions detected by CTC.

Copyright (c) 2010 AGA Institute. Published by Elsevier Inc. All rights reserved.

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