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Cell. 2010 Mar 19;140(6):935-50. doi: 10.1016/j.cell.2010.02.043.

Anti-inflammatory Agents: Present and Future.

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  • 1Department of Medicine, University of Colorado, Aurora, 80045, USA. cdinarello@mac.com

Abstract

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics.

2010 Elsevier Inc. All rights reserved.

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