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Cell. 2010 Mar 19;140(6):900-17. doi: 10.1016/j.cell.2010.02.034.

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease.

Author information

  • Department of Genetics and Complex Diseases, Broad Institute of Harvard and MIT, Harvard School of Public Health, Boston, MA 02115, USA. ghotamis@hsph.harvard.edu

Abstract

The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's adaptive capacity results in activation of the unfolded protein response (UPR), which intersects with many different inflammatory and stress signaling pathways. These pathways are also critical in chronic metabolic diseases such as obesity, insulin resistance, and type 2 diabetes. The ER and related signaling networks are emerging as a potential site for the intersection of inflammation and metabolic disease.

2010 Elsevier Inc. All rights reserved.

PMID:
20303879
[PubMed - indexed for MEDLINE]
PMCID:
PMC2887297
Free PMC Article

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