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Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.

Immunity, inflammation, and cancer.

Author information

  • 1Departments of Pharmacology and Pathology, University of California, San Diego, La Jolla, 92093, USA.

Abstract

Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.

2010 Elsevier Inc. All rights reserved.

PMID:
20303878
[PubMed - indexed for MEDLINE]
PMCID:
PMC2866629
Free PMC Article
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