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Prog Brain Res. 2009;179:107-15. doi: 10.1016/S0079-6123(09)17912-8. Epub 2009 Nov 20.

Modeling schizophrenia in flies.

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  • 1Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba, Japan.


Schizophrenia is a debilitating mental illness that affects 1% of the population worldwide. Although its molecular etiology remains unclear, recent advances in human psychiatric genetics have identified a large number of candidate genetic risk factors involved in schizophrenia. Modeling the disease in genetically tractable animals is thus a challenging but increasingly important task. In this review, I discuss the potential problems and perspectives associated with modeling schizophrenia in fruit flies, and briefly review the recent studies analyzing the molecular and cellular functions of Disrupted-In-Schizophrenia-1 (DISC1) in transgenic flies.

2009 Elsevier B.V. All rights reserved.

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