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    Rheumatol Int. 2011 Aug;31(8):1017-21. Epub 2010 Mar 19.

    Lack of association of FcγRIIIb polymorphisms with systemic lupus erythematosus: a meta-analysis.

    Yuan H, Ni JD, Pan HF, Li LH, Feng JB, Ye DQ.

    Source

    Department of Epidemiology and Biostatistics, Anhui Medical University, Anhui, People's Republic of China.

    Abstract

    Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Fcγ receptor genes have been suggested to play an important role in the pathogenesis of SLE and lupus nephritis (LN). This study aims to assess the association between FcγRIIIb-NA1/NA2 polymorphism and the susceptibility to SLE and lupus nephritis. Relevant studies were identified from electronic databases. A meta-analysis was performed for heterogeneity test and pooled OR calculation. The overall OR of NA2/NA2 homozygous genotype and NA2 allele frequency showed no significant association with SLE and lupus nephritis. Similarly, the association between FcγRIIIb-NA1/NA2 polymorphism and SLE and lupus nephritis was not found in European and Asian population. Taken together, our results suggest that FcγRIIIb might not be a susceptibility gene for SLE and lupus nephritis.

    PMID:
    20300756
    [PubMed - indexed for MEDLINE]

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