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Curr Opin Immunol. 2010 Jun;22(3):358-66. doi: 10.1016/j.coi.2010.02.012. Epub 2010 Mar 17.

Rational antibody-based HIV-1 vaccine design: current approaches and future directions.

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  • 1Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

Abstract

Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.

Copyright 2010 Elsevier Ltd. All rights reserved.

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