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Arthritis Rheum. 1991 May;34(5):631-3.

Systemic sclerosis associated with cutaneous exposure to solvent: case report and review of the literature.

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  • 1Rheumatology Section, Marshfield Clinic, Wisconsin 54449.


Sclerodermatous skin changes and systemic sclerosis have been reported to occur as a result of contact with several different organic solvents. We describe a 41-year-old man who developed systemic sclerosis after working for 15 years in a foundry, where he had extensive cutaneous contact with multiple organic solvents (trichloroethane, xylene, trimethylbenzene, and naphthalene). Cutaneous exposure to organic solvents may be a factor in the etiology of some cases of systemic sclerosis.

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