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Psychiatry Res. 2010 Apr 30;182(1):40-7. doi: 10.1016/j.pscychresns.2009.11.007. Epub 2010 Mar 16.

Improving 1H MRSI measurement of cerebral lactate for clinical applications.

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  • 1Neuroimaging Research Group, Department of Radiology, University of Washington, Seattle, WA 98105, USA. nevao@u.washington.edu


Accurate measurement of cerebral lactate is critical to the understanding of brain function for psychiatric disorders such as panic disorder and bipolar disorder as well as mitochondrial dysfunction. Proton magnetic spectroscopic imaging (MRSI) techniques can be used to study lactate in vivo; however, accurate measurement of cerebral lactate, which is normally at low basal abundance, can be challenging. In this study, regional lactate measurements obtained with two different MRSI analytic approaches were evaluated using proton echo-planar spectroscopic imaging (PEPSI) data from 18 healthy adults participating in an in vivo sodium lactate infusion study. The results demonstrate that averaging data within a region of interest (ROI) before spectral fitting with LCModel results in significantly improved lactate measurement as compared to averaging chemical concentrations derived from the fitting of individual voxels in the ROI. Simulation results that confirm this finding are also presented. This study additionally outlines an atlas-based approach for the systematic computation of regional distributions of chemical concentrations in large MRSI data sets.

Copyright @ 2009 Elsevier Ireland Ltd. All rights reserved.

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