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Am J Reprod Immunol. 2010 May;63(5):370-8. doi: 10.1111/j.1600-0897.2010.00811.x. Epub 2010 Mar 17.

Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activation.

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  • 1Department of Obstetrics and Gynecology, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL 60061, USA.



We aim to determine whether peripheral blood T cell activation is associated with repeated implantation failures or recurrent pregnancy losses (RPLs).


Women with a history of repeated implantation failure (n = 18) or RPLs (n = 17) comprise the study group. Normal fertile women (n = 11) are included as controls. Proportion of activated peripheral blood T cells (CD69(+), CD154(+)) and Th1/Th2 cell ratios are measured by flow cytometric analysis.


Proportions (%) of CD4(+)/154(+) of CD4(+) and CD8(+)/154(+) of CD8(+) cells were significantly higher in study group than those of controls. Proportions (%) of CD3(+)/69(+) of CD3(+) cells and CD8(+)/69(+) of CD8(+) cells were significantly increased in study group compared to controls. Proportion (%) of CD4(+)/69(+) cells significantly correlated with % CD4(+)/154(+) cells (P = 0.003). Activated cytotoxic T cells (CD8(+)/154(+), CD8(+)/69(+)) inversely correlated with INF-gamma/IL-10 producing CD3(+)/4(+) T cell ratios. Proportion of activated CD3(+)/8(+)/69 and CD3(+)/8(+)/154(+) cells was inversely correlated with IFN-gamma/IL-10 expressing CD3(+)/4(+) T cell ratios.


Women with MIFs or RPLs have increased T cell activation in peripheral blood lymphocytes, and T cell suppressor activation seems to be associated with decreased Th1 immunity. Further studies on T cell activation may elucidate molecular mechanisms controlling Th1 effectors.

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