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Endoscopy. 2010 Apr;42(4):279-85. doi: 10.1055/s-0029-1244020. Epub 2010 Mar 16.

Prevalence of nonpolypoid colorectal neoplasia: an Italian multicenter observational study.

Collaborators (149)

Crotta S, Strini G, Orsello M, Ballare M, Gallo M, Salacone P, Asnaghi G, Manca A, Rizzi R, Predebon S, Quattrone P, Vanni R, Di Placido R, Bastardini R, Cristoni MV, Praiano F, Meroni E, Fasoli A, Coccia G, Allegretti A, Manes G, Cesari P, Rolfi F, Zambelli A, Manfredi G, Lisi S, Cestari R, Lancini GP, Crosta C, Fiori G, De Roberto G, Dal Fante M, Fazzini L, Dinelli M, Frego R, Parente F, Bargiggia S, Paggi S, Viale E, Testoni PA, Buffoli F, Iiritano E, Andrian G, Dinca M, Germana B, Lecis P, Cappiello R, Sablich R, Tonello C, Buri L, Cannizzaro R, Maiero S, Fasoli R, Ceroni L, Eusebi LH, Iori V, Tioli C, Villani V, Cortini C, Maltoni S, Forti E, Solmi L, Giovanardi M, Calella F, Tarantino O, Widmayer C, Silvestrelli M, Bou Serhal T, Feliciangeli G, Tombesi G, Anti M, Pastorelli A, Costamagna G, Petruzziello L, Cesaro P, De Masi E, Errico A, Di Giulio E, Carnuccio A, Gabbrielli A, Pandolfi M, Lamazza A, Femia S, Morini S, Lorenzetti R, Del Vecchio Blanco G, Grasso E, Ferrara M, Apuzzo M, Iacopini F, Milano A, Balatsinou C, Spadaccini A, Silla M, Ingrosso M, Pirozzi GA, De Luca L, De Bellis M, Tempesta A, De Palma GD, Siciliano S, Di Giorgio P, Giannattasio F, Galloro G, Grimaldi E, Ciarleglio A, Sarrantonio G, Delle Cave M, Lamanda R, De Stefano S, Labianca O, Maisto T, Montanaro F, Pasquale L, Di Girolamo E, Piscopo R, De Seta M, Romano M, Borgheresi P, Romano M, Gravina AG, Sarracco P, Scaglione G, Marmo R, Salerno R, Gentile M, Annese V, Della Valle N, Muscatiello N, Di Matteo G, Giorgio P, Fregola G, Quatraro F, Pisani A, Tonti P, Stoppino G, Corazza L, D'Ascoli B, Ciuffi M, Ignomirelli O, Giglio A, Rodino S, Scanu AM, Loriga P, Murgia R, Giacobbe G, Grande D, Montalbano L, Linea C.

Erratum in

  • Endoscopy. 2010 Jul;42(7):563.

Abstract

BACKGROUND AND STUDY AIM:

The aim of this study was to assess the prevalence of nonpolypoid lesions (NPLs) in Italy and their risk of containing neoplasia or advanced histology.

PATIENTS AND METHODS:

This was a multicenter cross-sectional observational study on consecutive patients undergoing total colonoscopy over a 3-month period in 80 Italian centers.

RESULTS:

In all, 27,400 total colonoscopies were analyzed. Cancer was diagnosed in 801 patients (2.9 %). A total of 6553 precancerous lesions were detected in 5609 patients. Of these, 4154 patients (74.1 %) had polypoid lesions and 1455 patients (25.9 %) had NPLs. Therefore, the prevalence of NPLs was 5.3 % (95 %CI 5.0 - 5.6). NPLs larger than 10 mm were detected in 254 patients (17.5 %). NPLs were more predominant in the proximal colon (OR 2.92, 95 %CI 2.56 - 3.43; P < 0.0001 vs. polypoid lesions). Neoplastic tissue was diagnosed in 79.0 % and advanced histology (high-grade intraepithelial neoplasia or more) in 20.9 % of resected lesions. The risk of advanced histology was similar for polypoid and nonpolypoid lesions when adjusted for size. Depressed lesions had the highest risk of advanced histology (OR 10.56, 95 %CI 6.02 - 18.55; P < 0.0000 vs. flat-elevated). Age was an independent predictor of both neoplasia and advanced histology ( P = 0.0001).

CONCLUSIONS:

NPLs are relatively common in the Italian population, with a prevalence similar to that in other Western series. NPLs are not more aggressive than polypoid lesions, except for those with depressed morphology.

Georg Thieme Verlag KG Stuttgart. New York.

PMID:
20235006
[PubMed - indexed for MEDLINE]
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