Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Oral Dis. 2010 May;16(4):375-81. doi: 10.1111/j.1601-0825.2009.01649.x. Epub 2010 Mar 6.

Presence of Porphyromonas gingivalis and plasma cell dominance in gingival tissues with periodontitis.

Author information

  • 1Programs in Oromaxillofacial Infection & Immunity and BK21 CLS, Seoul National University, Seoul, Korea.

Abstract

OBJECTIVE:

Porphyromonas gingivalis can invade and survive within its host epithelial cells. The aim of this study was to test our hypothesis that persistent presence of intracellular periodontal pathogens in gingival tissue causes the chronic inflammation and that an inappropriate immune response is a risk factor for periodontitis.

METHODS:

Together with the presence of P. gingivalis, the distribution of B cells, plasma cells, and CD4(+), CD8(+), and FOXP3(+) regulatory T cells was evaluated in gingival tissues from healthy (n = 7) and periodontitis (n = 8) sites by in situ hybridization and immunohistochemistry, respectively.

RESULTS:

Porphyromonas gingivalis was detected in proximity to inflammatory infiltrates in three and seven biopsies from the healthy and periodontitis sites, respectively. Compared with healthy sites, periodontal lesions contained a significantly increased number of each immune cell studied with a relative dominance of plasma cells over T cells.

CONCLUSIONS:

Persistent bacterial invasion of gingival tissues in combination with a plasma cell-dominant immune response may be involved in the pathogenesis of periodontitis.

PMID:
20233323
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Blackwell Publishing
    Loading ...
    Write to the Help Desk