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Org Lett. 2010 Apr 16;12(8):1744-7. doi: 10.1021/ol100342m.

Engineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.

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  • 1Division of Pharmaceutical Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA.

Abstract

Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that overproduces 2 at a titer approximately 100-fold greater than that from the wild-type strain and accumulates platencin A(1) (3) and eight new congeners, platencins A(2)-A(9) (4-11). The isolation, structural elucidation, and antibacterial activity of 4-11, in comparison to 1-3, are described.

PMID:
20232845
[PubMed - indexed for MEDLINE]
PMCID:
PMC2855538
Free PMC Article
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