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J Back Musculoskelet Rehabil. 2010;23(1):21-3. doi: 10.3233/BMR-2010-0243.

Anti-cyclic citrullinated peptide antibodies are not associated with familial Mediterranean fever.

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  • 1Department of Physical Medicine and Rehabilitation, Medical Faculty, Ataturk University, 25240 Erzurum, Turkey. skaratay73@hotmail.com

Abstract

OBJECTIVE:

This study investigated the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in familial Mediterranean fever (FMF) patients and controls.

MATERIAL AND METHODS:

Forty-nine patients with FMF were enrolled (23 had a history of arthritis during attacks and 26 had no such history). Two control groups were enrolled: 20 patients with rheumatoid arthritis (RA) and 30 healthy individuals. Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), rheumatoid factor (RF), and anti-CCP antibody levels were measured.

RESULTS:

In RA patients' ESR and CRP levels, frequency of RF, and anti-CCP antibody levels were significantly higher than in both FMF patients and healthy controls (p 0.001). Moreover, anti-CCP was negative in all healthy controls as well as in all FMF patients.

CONCLUSION:

Our results show that anti-CCP antibodies are not associated with FMF.

PMID:
20231785
[PubMed - indexed for MEDLINE]
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