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Dev Cell. 2010 Mar 16;18(3):336-8. doi: 10.1016/j.devcel.2010.03.002.

Chromatin: the final frontier in splicing regulation?

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  • 1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.


Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.

Copyright 2010 Elsevier Inc. All rights reserved.

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