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Cell Host Microbe. 2010 Mar 18;7(3):179-81. doi: 10.1016/j.chom.2010.03.001.

The HIV-1 Tat team gets bigger.

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  • Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. arice@bcm.edu


Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.

Copyright 2010 Elsevier Inc. All rights reserved.

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