Display Settings:

Format

Send to:

Choose Destination
Cell Host Microbe. 2010 Mar 18;7(3):179-81. doi: 10.1016/j.chom.2010.03.001.

The HIV-1 Tat team gets bigger.

Author information

  • Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. arice@bcm.edu

Abstract

Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.

Copyright 2010 Elsevier Inc. All rights reserved.

Comment on

PMID:
20227660
[PubMed]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk