Contraception. 2010 Apr;81(4):275-80. doi: 10.1016/j.contraception.2009.11.007. Epub 2010 Jan 4.

Clinical pharmacokinetics and interaction of centchroman--a mini review.

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Pharmacokinetics and Metabolism Division, Central Drug Research Institute, CSIR, Lucknow, India. jlalcdri@rediffmail.com

Abstract

This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, centchroman has been used as a need-oriented contraceptive and is being given for treating dysfunctional bleeding of the uterus. Information regarding absorption, tissue distribution, elimination and kinetic interactions is discussed.

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Tissue distribution and pharmacokinetics of centchroman. A new nonsteroidal postcoital contraceptive agent and its 7-desmethyl metabolite in female rats after a single oral dose. [Drug Metab Dispos. 1996]
Tissue distribution and pharmacokinetics of centchroman. A new nonsteroidal postcoital contraceptive agent and its 7-desmethyl metabolite in female rats after a single oral dose.
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Cited by 3 PubMed Central articles

The role of sevista in the management of dysfunctional uterine bleeding. [J Clin Diagn Res. 2013]
The role of sevista in the management of dysfunctional uterine bleeding.
Bs D, Nanda SK. J Clin Diagn Res. 2013 Jan; 7(1):132-4. Epub 2012 Sep 10.
Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman. [PLoS One. 2012]
Polyphenols sensitization potentiates susceptibility of MCF-7 and MDA MB-231 cells to Centchroman.
Singh N, Zaidi D, Shyam H, Sharma R, Balapure AK. PLoS One. 2012; 7(6):e37736. Epub 2012 Jun 29.
Centchroman regresses mastalgia: a randomized comparison with danazol. [Indian J Surg. 2011]
Centchroman regresses mastalgia: a randomized comparison with danazol.
Tejwani PL, Srivastava A, Nerkar H, Dhar A, Hari S, Thulkar S, Chumber S, Kumar S. Indian J Surg. 2011 Jun; 73(3):199-205. Epub 2010 Nov 30.

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Clinical pharmacokinetics and interaction of centchroman--a mini review.
Clinical pharmacokinetics and interaction of centchroman--a mini review.
Contraception. 2010 Apr ;81(4):275-80. doi: 10.1016/j.contraception.2009.11.007. Epub 2010 Jan 4 .

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