Biol Blood Marrow Transplant. 2010 Jun;16(6):709-28. Epub 2010 Mar 12.

NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science.

Cairo MS, Jordan CT, Maley CC, Chao C, Melnick A, Armstrong SA, Shlomchik W, Molldrem J, Ferrone S, Mackall C, Zitvogel L, Bishop MR, Giralt SA, June CH.

Source

Department of Pediatrics, Medicine, and Pathology, Columbia University, Morgan Stanley Children's Hospital, New York-Presbyterian Hospital, New York, New York 10032, USA. mc1310@columbia.edu

Abstract

Hematopoietic malignant relapse still remains the major cause of death following allogeneic hematopoietic stem cell transplantation (HSCT). Although there has been a large focus on the immunologic mechanisms responsible for the graft-versus-tumor (GVT) effect or lack thereof, there has been little attention paid to investigating the biologic basis of hematologic malignant disease relapse following allogeneic HSCT. There are a large number of factors that are responsible for the biologic resistance of hematopoietic tumors following allogeneic HSCT. We have focused on 5 major areas including clonal evolution of cancer drug resistance, cancer radiation resistance, genomic basis of leukemia resistance, cancer epigenetics, and resistant leukemia stem cells. We recommend increased funding to pursue 3 broad areas that will significantly enhance our understanding of the biologic basis of malignant relapse after allogeneic HSCT, including: (1) genomic and epigenetic alterations, (2) cancer stem cell biology, and (3) clonal cancer drug and radiation resistance.

PMID:: 20227509; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Grant Support

Publication Types

Research Support, N.I.H., Extramural

MeSH Terms

Grant Support

U10 CA098543-08/CA/NCI NIH HHS/United States

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction. [Biol Blood Marrow Transplant. ...]
NCI First International Workshop on The Biology, Prevention, and Treatment of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on the Biology Underlying Recurrence of Malignant Disease following Allogeneic HSCT: Graft-versus-Tumor/Leukemia Reaction.
Miller JS, Warren EH, van den Brink MR, Ritz J, Shlomchik WD, Murphy WJ, Barrett AJ, Kolb HJ, Giralt S, Bishop MR, et al. Biol Blood Marrow Transplant. 2010 May; 16(5):565-86. Epub 2010 Feb 10.
Review NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: report from the Committee on the Epidemiology and Natural History of Relapse following Allogeneic Cell Transplantation. [Biol Blood Marrow Transplant. ...]
Review NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: report from the Committee on the Epidemiology and Natural History of Relapse following Allogeneic Cell Transplantation.
Pavletic SZ, Kumar S, Mohty M, de Lima M, Foran JM, Pasquini M, Zhang MJ, Giralt S, Bishop MR, Weisdorf D. Biol Blood Marrow Transplant. 2010 Jul; 16(7):871-90. Epub 2010 Apr 24.
Review NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. [Biol Blood Marrow Transplant. ...]
Review NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies.
Alyea EP, DeAngelo DJ, Moldrem J, Pagel JM, Przepiorka D, Sadelin M, Young JW, Giralt S, Bishop M, Riddell S. Biol Blood Marrow Transplant. 2010 Aug; 16(8):1037-69. Epub 2010 May 24.
Review Relapse after allogeneic hematopoietic cell therapy. [Biol Blood Marrow Transplant. ...]
Review Relapse after allogeneic hematopoietic cell therapy.
van den Brink MR, Porter DL, Giralt S, Lu SX, Jenq RR, Hanash A, Bishop MR. Biol Blood Marrow Transplant. 2010 Jan; 16(1 Suppl):S138-45. Epub 2009 Oct 24.
Review Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. [Dan Med Bull. 2007]
Review Alloreactivity as therapeutic principle in the treatment of hematologic malignancies. Studies of clinical and immunologic aspects of allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning.
Petersen SL. Dan Med Bull. 2007 May; 54(2):112-39.

See reviews... See all...

Cited by 3 PubMed Central articles

National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. [Biol Blood Marrow Transplant. ...]
National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee.
Bishop MR, Alyea EP 3rd, Cairo MS, Falkenburg JH, June CH, Kröger N, Little RF, Miller JS, Pavletic SZ, Porter DL, et al. Biol Blood Marrow Transplant. 2011 Apr; 17(4):443-54. Epub 2011 Jan 9.
Review Minimal residual disease following allogeneic hematopoietic stem cell transplantation. [Biol Blood Marrow Transplant. ...]
Review Minimal residual disease following allogeneic hematopoietic stem cell transplantation.
Kröger N, Miyamura K, Bishop MR. Biol Blood Marrow Transplant. 2011 Jan; 17(1 Suppl):S94-100. Epub 2010 Nov 1.
NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation. [Biol Blood Marrow Transplant. ...]
NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: Report from the Committee on Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.
Porter DL, Alyea EP, Antin JH, DeLima M, Estey E, Falkenburg JH, Hardy N, Kroeger N, Leis J, Levine J, et al. Biol Blood Marrow Transplant. 2010 Nov; 16(11):1467-503. Epub 2010 Aug 10.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

NCI first International Workshop on the biology, prevention, and treatment of re...
NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science.
Biol Blood Marrow Transplant. 2010 Jun ;16(6):709-28. Epub 2010 Mar 12 .

PubMed
The nuclear vitamin D receptor controls the expression of genes encoding factors...
The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging.
J Steroid Biochem Mol Biol. 2010 Jul ;121(1-2):88-97. Epub 2010 Mar 20 .

PubMed
Differential effects of planning and self-efficacy on fruit and vegetable consum...
Differential effects of planning and self-efficacy on fruit and vegetable consumption.
Appetite. 2010 Jun ;54(3):611-4. Epub 2010 Mar 20 .

PubMed
A truncated species of apolipoprotein B (B67) in a kindred with familial hypobet...
A truncated species of apolipoprotein B (B67) in a kindred with familial hypobetalipoproteinemia.
J Clin Invest. 1991 May ;87(5):1748-54.

PubMed
Molecular pathways and agents for lowering LDL-cholesterol in addition to statin...
Molecular pathways and agents for lowering LDL-cholesterol in addition to statins.
Pharmacol Ther. 2010 Jun ;126(3):263-78. Epub 2010 Mar 19 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: