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Curr Opin Microbiol. 2010 Jun;13(3):255-62. doi: 10.1016/j.mib.2010.02.001. Epub 2010 Mar 11.

Toward design-based engineering of industrial microbes.

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  • 1Department of Chemical and Biological Engineering, Chalmers University of Technology, Göteborg SE-412 96, Sweden.


Engineering industrial microbes has been hampered by incomplete knowledge of cell biology. Thus an iterative engineering cycle of modeling, implementation, and analysis has been used to increase knowledge of the underlying biology while achieving engineering goals. Recent advances in Systems Biology technologies have drastically improved the amount of information that can be collected in each iteration. As well, Synthetic Biology tools are melding modeling and molecular implementation. These advances promise to move microbial engineering from the iterative approach to a design-oriented paradigm, similar to electrical circuits and architectural design. Genome-scale metabolic models, new tools for controlling expression, and integrated -omics analysis are described as key contributors in moving the field toward Design-based Engineering.

Copyright 2010 Elsevier Ltd. All rights reserved.

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