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Chromosoma. 2010 Aug;119(4):391-404. doi: 10.1007/s00412-010-0264-y. Epub 2010 Mar 12.

Positional variations among heterogeneous nucleosome maps give dynamical information on chromatin.

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  • 1Department of Medical Genome Sciences, University of Tokyo, Minato-ku, Japan.

Abstract

Although nucleosome remodeling is essential to transcriptional regulation in eukaryotes, little is known about its genome-wide behavior. Since a number of nucleosome positioning maps in vivo have been recently determined, we examined if their comparisons might be used for obtaining a genome-wide profile of nucleosome remodeling. Using seven yeast maps, the local variability of nucleosomes, measured by the entropy, was significantly higher in a set of reported unstable nucleosomes. The binding sites of four transcription factors, known as the remodeling factors, were distinctively high both in entropy and linker ratio, whereas those of Yhp1, their potential inhibitor, showed the lowest values in both of them. Taken together, our map shows the general information of nucleosome dynamics reasonably well. The "nucleosome dynamics" map provides the new significant correlation with the degree of expression variety instead of their intensity. Furthermore, the associations with gene function and histone modification were also discussed here.

PMID:
20224866
[PubMed - indexed for MEDLINE]
PMCID:
PMC2926881
Free PMC Article
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