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Science. 2010 Mar 26;327(5973):1644-8. doi: 10.1126/science.1184008. Epub 2010 Mar 11.

A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae.

Author information

  • 1Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.

Abstract

Extracellular matrices in diverse biological systems are cross-linked by dityrosine covalent bonds catalyzed by the peroxidase/oxidase system. We show that a peroxidase, secreted by the Anopheles gambiae midgut, and dual oxidase form a dityrosine network that decreases gut permeability to immune elicitors. This network protects the microbiota by preventing activation of epithelial immunity. It also provides a suitable environment for malaria parasites to develop within the midgut lumen without inducing nitric oxide synthase expression. Disruption of this barrier results in strong and effective pathogen-specific immune responses.

PMID:
20223948
[PubMed - indexed for MEDLINE]
PMCID:
PMC3510679
Free PMC Article

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