Nature. 2010 Mar 11;464(7286):217-23.

Targeting early infection to prevent HIV-1 mucosal transmission.

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Department of Microbiology, University of Minnesota, Minnesota 55455, USA. haase001@umn.edu

Abstract

Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.

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Targeting early infection to prevent HIV-1 mucosal transmission.

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