Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Trends Genet. 2010 Apr;26(4):149-53. doi: 10.1016/j.tig.2010.01.004. Epub 2010 Mar 10.

On the origin of MADS-domain transcription factors.

Author information

  • 1Department of Genetics, Friedrich Schiller University Jena, D-07743 Jena, Germany.


MADS-domain transcription factors are involved in signal transduction and developmental control in plants, animals and fungi. Because their diversification is linked to the origin of novelties in multicellular eukaryotes, the early evolution of MADS-domain proteins is of interest, but has remained enigmatic. Employing whole genome sequence information and remote homology detection methods, we demonstrate that the MADS domain originated from a region of topoisomerases IIA subunit A. Furthermore, we provide evidence that gene duplication occurred in the lineage that led to the MRCA of extant eukaryotes, giving rise to SRF-like and MEF2-like MADS-box genes.

Copyright 2010 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk