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Curr Biol. 2010 Mar 9;20(5):R240-2. doi: 10.1016/j.cub.2010.01.011.

Transcriptional memory: mothers SET the table for daughters.

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  • Program in Molecular Medicine, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA. craig.peterson@umassmed.edu <craig.peterson@umassmed.edu>

Abstract

Eukaryotic gene transcription within individual cells of a population is often associated with heterogeneous pulses of gene activity. A recent study, however, shows that mothers and their daughters share similar transcriptional frequencies, and inheritance of mother's transcriptional tendencies requires methylation of histone H3 by a Set1 methyltransferase.

PMID:
20219175
[PubMed - indexed for MEDLINE]
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