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Platelets. 2010;21(4):239-43. doi: 10.3109/09537101003639931.

CalDAG-GEFI and platelet activation.

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  • 1Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, PA, USA.


Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. Here, we review recent findings, which (a) identified CalDAG-GEFI (RasGRP2) at the nexus of the rapid Ca(2+)-dependent platelet activation, (b) demonstrated a complex synergy between signaling provided by CalDAG-GEFI, protein kinase C and the Gi-coupled receptor for ADP, P2Y12, and (c) suggested CalDAG-GEFI as a novel target for anti-platelet therapy.

[PubMed - indexed for MEDLINE]
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