Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
RNA Biol. 2010 Mar-Apr;7(2):192-204. Epub 2010 Mar 14.

Spliceosomal snRNA modifications and their function.

Author information

  • 1Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.

Abstract

Spliceosomal snRNAs are extensively 2'-O-methylated and pseudouridylated. The modified nucleotides are relatively highly conserved across species, and are often clustered in regions of functional importance in pre-mRNA splicing. Over the past decade, the study of the mechanisms and functions of spliceosomal snRNA modifications has intensified. Two independent mechanisms behind these modifications, RNA-independent (protein-only) and RNA-dependent (RNA-guided), have been discovered. The role of spliceosomal snRNA modifications in snRNP biogenesis and spliceosome assembly has also been verified.

PMID:
20215871
[PubMed - indexed for MEDLINE]
PMCID:
PMC4154345
Free PMC Article

Images from this publication.See all images (5)Free text

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Landes Bioscience Icon for PubMed Central
    Loading ...
    Write to the Help Desk