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RNA Biol. 2010 Mar-Apr;7(2):192-204. Epub 2010 Mar 14.

Spliceosomal snRNA modifications and their function.

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  • 1Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.


Spliceosomal snRNAs are extensively 2'-O-methylated and pseudouridylated. The modified nucleotides are relatively highly conserved across species, and are often clustered in regions of functional importance in pre-mRNA splicing. Over the past decade, the study of the mechanisms and functions of spliceosomal snRNA modifications has intensified. Two independent mechanisms behind these modifications, RNA-independent (protein-only) and RNA-dependent (RNA-guided), have been discovered. The role of spliceosomal snRNA modifications in snRNP biogenesis and spliceosome assembly has also been verified.

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