Cell. 2010 Mar 5;140(5):608-10.

Preview. Angelman syndrome: finding the lost arc.

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Division of Biology, Caltech, Pasadena, CA 91125, USA.

Abstract

Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome.

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Cell. 2010 Mar 5;140(5):704-16.

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The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. [Cell. 2010]
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.
Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, et al. Cell. 2010 Mar 5; 140(5):704-16.
Angelman syndrome: advancing the research frontier of neurodevelopmental disorders. [J Neurodev Disord. 2011]
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Matsuura T, Sutcliffe JS, Fang P, Galjaard RJ, Jiang YH, Benton CS, Rommens JM, Beaudet AL. Nat Genet. 1997 Jan; 15(1):74-7.
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Preview. Angelman syndrome: finding the lost arc.

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